http://en.wikipedia.org/wiki/Model-dependent_realismquotes from the book "The Grand Design" (Stephen Hawking):
"[Model-dependent realism] is based on the idea that our brains interpret the input from our sensory organs by making a model of the world. When such a model is successful at explaining events, we tend to attribute to it, and to the elements and concepts that constitute it, the quality of reality or absolute truth."
"There is no picture- or theory-independent concept of reality. Instead we will adopt a view that we will call model-dependent realism: the idea that a physical theory or world picture is a model (generally of a mathematical nature) and a set of rules that connect the elements of the model to observations. This provides a framework with which to interpret modern science."
"According to model-dependent realism, it is pointless to ask whether a model is real, only whether it agrees with observation. If there are two models that both agree with observation ... then one cannot say that one is more real than another. One can use whichever model is more convenient in the situation under consideration."
"It might be that to describe the universe, we have to employ different theories in different situations. Each theory may have its own version of reality, but according to model-dependent realism, that is acceptable so long as the theories agree in their predictions whenever they overlap, that is, whenever they can both be applied."
"According to the idea of model-dependent realism ..., our brains interpret the input from our sensory organs by making a model of the outside world. We form mental concepts of our home, trees, other people, the electricity that flows from wall sockets, atoms, molecules, and other universes. These mental concepts are the only reality we can know. There is no model-independent test of reality. It follows that a well-constructed model creates a reality of its own."
In other words, our model is only as good as our ability to observe events. This is an extension of one of the basic organising principles of modern science, that a model is only as good as its ability to predict events. Hawking associated himself with the commonly assumed principle of 'model dependent realism' by giving it that name.
I am reading this book but it's in French and the best way to illustrate the point to you is by copy-pasting from Wikipedia, at least it's in english
You might be interested in reading the book, it is very interesting.